Quote (blind_chief @ Sat - May 21 2011 - 22:33:09)
Quote (Du$tin @ Sat - May 21 2011 - 19:59:19)
Quote (Zodijackyl @ Fri - May 20 2011 - 19:16:45)
his family confirmed that it was an overdose of alcohol and oxycodone
alcohol is still cool though, no worries
anyone who drinks alcohol will die
the abuse of pills plays no part
actually in this case it really does. oxycodone is a potent respiratory depressant. alcohol is only minor in that field, but potentiates the effects from the oxycodone. Breathing rate slows, slows, slows, and at some point just stops. Had he just drank that night and not taken the pills, he would have likely been fine (assuming he didnt way overdo the drinking) and likewise with the pills.
Now to understand why this is important is to understand why we breathe. #1 misconception of the process of breathing is that we breathe because we need oxygen. While this is true in some regards, the actual mechanism of breathing has nothing to do with oxygen. The intake of oxygen is a "side effect" of breathing. Humans actually breathe because of a drop in pH in the blood caused by accumulation of carbon dioxide in the bodys circuitry. CO2 is not an acid, but in solution with water turns into carbonic acid (H2CO3), hence lowering of the body's pH. This change of pH is picked up in the brain, which stimulates more effective breathing (more breathing is more exhaling, more CO2 burned off). oxycodone increases the ceiling threshold of the brain's pH sensor (resulting in greater allowed fluctuation of pH in blood). blood pH should be around 7.4, and marked effects on the body can start occuring as early as 7.2
tldr -> anyone who mixes any sedative with alcohol is an idiot and probably will die from it (includes steve).
PPS to tldr: over time the receptors develop tolerance to deliver the sedative effect while not changing the tolerance for blood pH monitoring. assuming prescription strength of a medication doesnt change for the abuser, that means they will likely over time require more beer to achieve the same effect of whatever it was they were looking for, but each time increasing the amount of respiratory depression and chance to not wake up.